Effect of Artichoke Extract on Hypercholesterolemic Status of Bile Duct Ligation Rat Model

Dr. Aisha I M Adawi; Prof. Dr. Tuncay veysel PEKER

Effect of Artichoke Extract on Hypercholesterolemic Status of Bile Duct Ligation Rat Model

Authors: Dr. Aisha I M Adawi(1), Prof. Dr. Tuncay veysel PEKER(2)
Ph.D. Student, Department of Anatomy, Institute of Health Sciences, Gazi University, Ankara, Turkey.(1)
Prof. Doctor in Anatomy, Department of Anatomy, Faculty of Medicine, Gazi University, Ankara, Turkey.(2)
Email: aishaadawi@yahoo.com
Doi: doi.org/10.52132/Ajrsp.e.2022.39.3

Abstract:

Objective: Dietary plants have gained great attention, because they can play important role in enhancement of health and wellbeing. The purpose of our study was to look into the effect of artichoke extract on hypercholesterolemic status of bile duct ligation rat model. Materials and Methods: In this study we used 21 Wistar albino rats. They randomly assigned into three groups; Group 1 (control group) underwent laparotomy alone and the common bile duct was only exposed and no drug was applied. Group 2 (BDL group) was subjected only to bile duct ligation (BDL) and no drug was applied. Group 3 (BDL +Ac) received a daily dose of 1.5 g/kg/per os of artichoke extract starting 24 hours after BDL. After 7 days of treatment, the animals were sacrificed, the blood samples were taken and total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels were analysed. Results: TC decreased in BDL+ Ac group compared to BDL group (44.42±21.19, 61.2±11.3). The LDL-C decreased in BDL+ Ac group compared to BDL group (28,5±10,05, 38,4±3,91) with a statistical significance (p<0,05). HDL decreased in BDL group and in BDL+ Ac group compared to the control group; however, it indicated no statistically significant difference (p>0,05). Conclusion: In this research, artichoke extract application may improve hypercholesterolemic status of bile duct ligation. Further studies with larger volume are required to support our promising results.

Keywords:

Hypercholesterolemia, Artichoke, Cholestasis, Bile duct ligation, Rat

Download PDF

AJRSP

International peer-reviewed journal
Established in 2019
ISSN: 2706-6495
Email: editor@ajrsp.com

Ongoing Issue: 78
Publication Date:
5 October 2025

Peer-Review statement

All articles published in this journal undergo a rigorous double-blind peer review by independent experts to ensure academic integrity and research quality.

Review Timeline

Avg. Time for Desk Review:
1–2 weeks
Avg. Time per Review Round:
3–4 weeks