Effect of Artichoke Extract on Hypercholesterolemic Status of Bile Duct Ligation Rat Model
Authors: Dr. Aisha I M Adawi(1),
Prof. Dr. Tuncay veysel PEKER(2)
Abstract: Objective: Dietary plants have gained great attention, because they can play important role in enhancement of health and wellbeing. The purpose of our study was to look into the effect of artichoke extract on hypercholesterolemic status of bile duct ligation rat model. Materials and Methods: In this study we used 21 Wistar albino rats. They randomly assigned into three groups; Group 1 (control group) underwent laparotomy alone and the common bile duct was only exposed and no drug was applied. Group 2 (BDL group) was subjected only to bile duct ligation (BDL) and no drug was applied. Group 3 (BDL +Ac) received a daily dose of 1.5 g/kg/per os of artichoke extract starting 24 hours after BDL. After 7 days of treatment, the animals were sacrificed, the blood samples were taken and total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels were analysed. Results: TC decreased in BDL+ Ac group compared to BDL group (44.42±21.19, 61.2±11.3). The LDL-C decreased in BDL+ Ac group compared to BDL group (28,5±10,05, 38,4±3,91) with a statistical significance (p<0,05). HDL decreased in BDL group and in BDL+ Ac group compared to the control group; however, it indicated no statistically significant difference (p>0,05). Conclusion: In this research, artichoke extract application may improve hypercholesterolemic status of bile duct ligation. Further studies with larger volume are required to support our promising results. Keywords: Hypercholesterolemia, Artichoke, Cholestasis, Bile duct ligation, Rat Download PDF |
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Academic Journal of Research and Scientific Publishing